No. 2 Can the Jaguars force 49ers QB Bruck Purdy into making mistakes?
Containing Christian McCaffrey Sunday is just one part of the equation. The Jaguars will also need to account for Bruck Purdy, who made veteran Jimmy Garappolo expendable in the offseason. Purdy, the very last pick in last year's draft, is currently in a funk but he's proven to be capable of running the 49ers offense smoothly.
Purdy has thrown just three touchdown passes and five interceptions the last three games. Moreover, his completion rate drops a full 12.0 percent on the road and his quarterback rating is 39 points lower. On the other hand, he's had enough time to adjust in the BYE, and having Deebo Semual and his full arsenal of weapons could help him get back on track.
On the other hand, starting left guard Aaron Banks has been ruled out and there's a chance left tackle Trent Williams, who's listed as questionable, might not suit up. That would give the Jaguars pass rush, more specifically outside linebacker Josh Allen, a favorable matchup.
This is why it will be so important for the Jaguars to shut down the run on early downs and force the 49ers offense into third-and-long situations. Working in their favor is that they'll likely get cornerback Tyson Campbell and safety Andre Cisco back for the game.
Campbell, along with fellow cornerback Darious Williams, will need to handle their assignments and force Purdy to hold onto the football. If they do, Josh Allen will have ample opportunities to get to him.