No. 1 Will the Jaguars O-Line be able to contain Nick Bosa and Chase Young?
The 49ers have built a stout defensive front this season. They already had Arik Armstead and Nick Bosa in the fold but they added Javon Hargrave in free agency and later traded for Chase Young at the trade deadline. Although San Francisco only has 18 sacks, they created pressures at a high rate and had one of the best win rates in the league. With Young now in the mix, they'll be more difficult to contain.
The good news is that the Jaguars will be getting offensive line Walker Little for Week 10. Little missed the last three games with a knee injury but he's fully healthy and ready to line up at left guard. Another thing that will help Jacksonville neutralize the 49ers pass rush is Lawrence's ability to make quick decisions and not hold onto the football. His 2.48 seconds to throw is the fourth-best time in the league.
Lawrence's numbers don't pop off of the stat sheet but he's been highly efficient during the Jags' five-game winning streak, throwing for seven touchdowns with just two interceptions and completing 70.9 percent of his passes. Furthermore, he ranks 16th with 16 big-time throws and his deep passing grade (throws of 20+ yards) leads the league.
The bottom line is that containing the 49ers defensive front won't be easy but if the offensive line can give Lawrence enough time to throw, their chances of winning the game will go up.