Jaguars vs. Colts game today: How to watch, Time, Stream, Odds, Injuries & More

The Jacksonville Jaguars beat the Indianapolis Colts in the opener. These AFC South are set to face each other again for a rematch in Week 6. Both teams are 3-2 and whoever wins will be in sole control of the division. Trevor Lawrence, for one, is aware of how important this game will be.

"It's a big week. Anytime you play a division opponent, it's big. It's only Week 6, there's a lot that can happen as the season goes on, but we're tied for first in the division. I think they're 2-1, we're 1-1 in the division, so this is a big game," Lawrence told the media Wednesday. "You look at it, we can go 2-1 or they can go 3-1 and that's a big swing."

"So for us, we understand the importance of it. They do too, there's no secrets. You're not gonna surprise anyone in games like this but it's a great opportunity for us to continue to go the way we want to go this season. This is the next step and we got to take it one week at a time. This is really a good team that's playing really well right now," Lawrence said.

With a win, the Jaguars will narrow down the gap with the top teams in the AFC while a loss will send them to second place in the division. With that in mind, here's everything you need to know for the Week 6 rematch between Jacksonville and the Colts.

Jaguars vs. Colts Injury Report for Week 6

The Jags have already ruled out wide receiver Calvin Ridley and offensive lineman Walker Little. Devin Lloyd is listed as questionable with a thumb injury but he could play in Week 6 after missing the past two games. Defensive end Dawuane Smoot, for his part, is set to make his season debut against Indy.

Smoot spent the offseason recovering from the Achilles tear he suffered last year. He started the 2023 season on the Injured Reserved but his window to practice was opened before Jacksonville traveled to London. The former Illinois Fighting Illini hasn't had any setbacks and says he's ready to help the Jags win games.

On the other side of the aisle, right tackle Braden Smith won't be suiting up for the Colts. Tight end Mo Alie-Cox (concussion) and center Ryan Kelly (ankle) are questionable for the game. Defensive end Kwity Paye and left tackle Bernhard Raimman were in the concussion protocol but both are cleared to play.

Jaguars vs. Colts Inactives for Week 6

Here are the inactives for Week 6:
Zay Jones
JaMycal Hasty
Yasir Abdullah
Walker Little

Jaguars vs. Colts Odds/Spread for Week 6

The Jags are a 4-point favorite with a moneyline of -200, per DraftKings. Place a wager of $200 on them and win $100 if they beat Indy. The Colts' moneyline sits at +180. Bet $100 and win $180 for a total payout of $280 if they come on top in Week 6. The over/under for the game is 44.5 points.

Jaguars vs. Colts: How to watch/listen to the Week 6 division game

This one will start at 1:00 p.m. ET/12:00 p.m. CT. It will be shown on CBS, NFL Network and ESPN+. Spero Dedes and Adam Archuleta will provide live analysis from the booth while Amanda Renner reports from the sidelines.

You can also catch the game on WJXL 1010 AM/92.5 FM, as well as on 99.9 FM Gator Country. Frank Frangie, Jeff Lageman and Toney Boselli will be the booth analysts and Bucky Brooks will handle sideline duty.

Jaguars vs. Colts Stream for Week 6

You can find a stream of the game on FuboTV. All you need is an internet connection to watch the game in a computer, tablet, or mobile. Sign here for your free seven-day trial.

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